fMRI assessment of language lateralization: An objective approach

DF Abbott; AB Waites; LM Lillywhite; GD Jackson

Journal article

fMRI assessment of language lateralization: An objective approach

DF Abbott, AB Waites, LM Lillywhite, GD Jackson

Neuroimage | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2010

DOI: 10.1016/j.neuroimage.2010.01.059

Abstract

Language lateralization based on functional magnetic resonance imaging (fMRI) is often used in clinical neurological settings. Currently, interpretation of the distribution, pattern and extent of language activation can be heavily dependent on the chosen statistical threshold. The aim of the present study was to 1) test the robustness of adaptive thresholding of fMRI data to yield a fixed number of active voxels, and to 2) develop a largely threshold-independent method of assessing when individual patients have statistically atypical language lateralization. Simulated data and real fMRI data in 34 healthy controls and 4 selected epilepsy patients performing a verbal fluency language fMRI tas..

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University of Melbourne Researchers

David Abbott Author

Graeme Jackson Author

Related Projects (1)

Epilepsy: Molecular basis and mechanisms in the era of functional genomics

The team comprises of neurologists with a special interest in epilepsy (both adult and child) molecular geneticists, physiologists and brain..

Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

The authors would like to thank Marnie E. Shaw for helpful discussions during preparation of the manuscript, and acknowledge funding from the National Health and Medical Research Council of Australia (primarily NHMRC project grant 368650; some data used were acquired as part of program grant 400121 and project grants 318900 and 226100).